1801006094 CASE PRESENTATION

 Long Case


13 Y/F came to OPD with chief complaints of

* Shortness of breath since yesterday

* 4 episodes of vomitings (since 10 am , yesterday)


HISTORY OF PRESENTING ILLNESS

Patient was apparently asymptomatic till the age of 11years when  she noticed  bilateral multiple neck swellings ,non mobile associated with pain.

She was taken to local hospital with complaints of neck swellings,fever and cough (on and off)

They initiated her on ATT( Anti tubercular drugs) as her mother has also has kochs

She used ATT for 2months started in 2021 june

After initiating ATT, fever did not subside,  so they stopped ATT and was referred to Hyderabad.

Patient was taken to X hospital where she was evaluated for kochs but none of the investigations showed Acid fast bacilli.

At the same time she also had complaints of knee pains and wrist joint pains

In view of joint pains she was referred to Y hospital 

In Y hospital they suspected it to be AUTOIMMUNE

And  started her on 

Tab Wysolone 

Tab Hydroxychloroquine 

which she used for 15 days and stopped ( symptoms subsides) and later did not go there for follow up

(ANA ELISA-equivocal,

ANA IFA-negative,

Anti Ds DNA ELISA-Positive,

Anti Ds DNA IFA negative)

She was taken to another local hospital with c/o joint pains,facial puffiness,pedal edema,fever ,cough

Lymph node biopsy was done in May 2022 ?reactive(no report available but attendor was informed that it was negative for kochs)

So Mycobacterial gene expert test was done on blood sample which was also negative

But she was initiated on ATT empirically on may/2022.

In June 2022 she started developing pigmentation/rash over face which then was seen on scalp evident because of hair loss and on trunk since 3 months,not associated with itching.

And also pedal edema upto ankles which then progressed till knee in the last 3 months(pitting type)

Then she was taken to area hospital and got tested and the attender(father) was informed that she has tuberculosis. 

Lymph node  biopsy was done

Mycobacterial gene expert test was done 

No reports available

So they started her on ATT and recieved regular treatment for 6m.

Her symptoms settled and she was fine until January 10 when she develop edema again (generalized)

They went to another hospital and got tested and was told to have proteinuria.

In January and February she had mild fever and 1 week back she developed fever and edema again.


On 13 March

From 10 am in the morning

Patient had 4 episodes of vomitings, after 2 hrs of food intake , non bilious and non blood stained, food particles and water as content. 

She also complains of nausea

Patient later on the same day developed shortness of breath of Grade 3 ( NYHA) 





PAST HISTORY

K/C/o e

Extra pulmonary tuberculosis (1year back used att for 6 months)

N/k/c/o hypertension, Diabetes mellitus, epilepsy, asthma, coronary artery disease, cardiovascular disease.


TREATMENT HISTORY

Used ATT for 6 months for TB




Birth and Family history

1st child 

2nd degree consanguineous marriage 

Born in 2010

LSCS

Father has no idea about immunisation status

Mother-has 2 children

The current pt is the elder one(birth in 2010)

2nd child born in 2013

In 2014 mother diagnosed with kochs - expired in 2022 sept(did not use ATT regularly)


PERSONAL HISTORY

Single

Occupation:student

Diet - Mixed

Appetite - Decreased 

Sleep - Adequate

Bowel and bladder - Regular 

No addictions.


DAILY ACTIVITY 

Earlier at Hostel


5 am wake up

Gets ready by 6 am

6:30 am to the ground for yoga,exercises 

7 am ragi Java

7.30 am prayer 

8am classes 

9.15 am breakfast 

Classes until 1.30

1.30 to 2.30 lunch

2.30 to 4.30 study hour

4.30 to 5 snacks

5.00 to 6 pm walking ,playing 

6 to 6.30 prayer

7 pm dinner

Till 9 pm study hour

9pm sleep 


Now at Home


6am wake up

7 am tea

Breakfast and fruits 

Tablets 

Sleeps until afternoon

2.30 to 3 lunch

2 months after taking ATT her appetite was increased and she ate more food ,more frequently (5times a day).

Walking exercises 

Evening 6pm fruits

Songs prayers

8pm dinner

9pm sleep 


GENERAL EXAMINATION:


Patient is conscious, coherent and co-operative,well oriented to time,place and person.

Moderately build and malnourished.

Examination was done in a well lit room.

Pallor+

Pedal edema + ( grade 2)

No icterus, cyanosis,clubbing,lymphadenopathy






VITALS

BP:140/90 bpm 

PULSE RATE:80/min regular normal volume

RESPIRATORY RATE: 26 cycles/min

Spo2 : 95%RA

Temperature chart



 SYSTEMIC EXAMINATION


ABDOMEN 

Inspection


Shape - Slightly distention.

Umbilicus - Everted

Equal movements in all the quadrants with respiration.

No visible pulsation,peristalsis, dilated veins and localized swellings.

No scars , sinuses 


Palpation


Soft, tenderness in right and left Hypochondrium, epigastrium.

Fluid thrill present 


Percussion


Shifting dullness present

Auscultation

Bowel sounds heard


RESPIRATORY SYSTEM 


Bilateral air entry present

Dull note all over 

Vocal resonance decreased


CVS EXAMINATION 

S1 S2 heard( Slightly muffled), no murmurs

Pericardial rub heard


CNS EXAMINATION 

No focal neurological deficits

Higher mental functions normal

Cranial nerves normal

Sensory examination normal sensations

Motor examination normal

Reflexes normal


INVESTIGATIONS

Spot urine sodium 166mmol/l

Spot urinary potassium 20.5


ABG

PH 7.4

Pc02 14.9 mm hg 

P02 79.8mm hg

Hc03 9.2 mmol/l

O2 saturation 96%


SERUM ELECTROLYTES on 14\3


Sodium 136 meq/l

Potassium 4.4 mEq/l

Chloride 106 meq/l


Serum creatinine 0.6mg/dl

ESR 70 mm

CRP NEGATIVE 


Blood urea 29 mg\dl

FBS 100 mg\dl

Blood group 0+

Rheumatoid factor negative

HIV non reactive

Hbs ag non reactive


URINE EXAMINATION 

Colour pale yellow

Appearance clear

Acidic

Specific gravity 1.010

Albumin ++

No sugar, bile salts, bile pigments, rbc, crystals, casts, amorphous deposits

Pus cells 3 to 4 \hpf

Epithelial cells 2 to 3 \hpf


USG

Liver,gallbladder,pancreas,spleen, uterus,ovaries normal

Moderate ascites

Bilateral pleural effusion

Moderate pericardial effusion

Bilateral grade 2 RPD changes


COMPLETE BLOOD PICTURE 

Hb 7.5 g\dl

WBC 4200 cells\cumm

Neutrophils 60

Lymphocytes 36

Eosinophils 02

Monocytes 02

Basophils 0

Pcv 24.6 vol%

Mch 76.4 fl

Mchc 30.5%

Rdw 20.6 %

Rbc count 3.2 million\cumm

Platelet 1.57 laksh\cumm

Smear normocytic normochromic anemia


On 15\3

Serum creatinine 1.0 mg\dl

Sodium 1.37 meq\l

Potassium 4.7

Chloride 104

Spot urine protein 393 mg\dl

Spot urine creat 37.8 mg\dl

Ratio 10.3


ECG


X RAY







2D ECHO


















PROVISIONAL DIAGNOSIS

Autoimmune Disease??
Glomerulonephritis secondary to Lupus nephritis??
Systemic lupus erythematosus??( Effecting skin, kidney , joints, serositis)??
Drug induced ( cutaneous and renal impairment)??
Pleural effusion
Pericardial effusion 


TREATMENT 

Fluid restriction ( 1.5 L/day)

Salt restriction (1.2 GM/day)

Inj lasix 40mg IV BD

Inj Monocef 1gm IV BD

Inj Methyl prednisolone 250mg in 100ml NS IV OD

Tab Aldactone 25mg PO OD

Tab Shelcal 500mg PO OD

Vitals monitoring


----------------------------------------------------------------------------------------------------------------------------------------------------

Short Case


A 55yr old male came with the chief complaints of

*Tingling and Burning sensation in left leg and left hand since 15 days

*Chest pain since 6days 


HISTORY OF PRESENTING ILLNESS

Patient was apparently asymptomatic 6yrs ago then he had an episode of sudden loss of consciousness associated with excessive sweating, which was associated with slurring of speech,  deviation of mouth towards right.

He was taken to hospital in karimnagar and diagnosed with left hemiparesis and is under medication (anti platelets) till date.

He now  presents with the complaint of burning sensation in the left upper  and lower limb since 15 days which is persistent throughout day.

He also complains of  right sided chest pain which is sudden onset ,dragging type , non radiating, intermittent in nature not associated with shortness of breath ,sweating .

Patient complaints of generalized  weakness since 1 year

No history of any other episodes of loss of consciousness, seizures,headache , nausea,vomitings .


PAST HISTORY

Patient had a history of trauma to head 20 years ago( was beaten up by thieves)

For which suture were done and medications were taken

Not a known case of DM,HTN,Epilepsy,Asthma and coronary artery disease.

H/o Right eye cataract surgery 1 year ago .




DAILY ROUTINE

He daily wakes up at 5am ,does his daily routine walk with stick and eats breakfast at 8 am.Then he watches tv and have lunch at 1 pm sleeps for about 2hrs and the go for walk with stick and have dinner at 8:00 PM and sleep at 10:00 PM.


PERSONAL HISTORY:

Diet: Mixed 
Appetite: decreased since 2 months
Bowel - hard stools once in 2 months
Bladder- burning micturation since 2 months
Sleep:Adequate 
Addictions- Smoking since 40yrs ( one bidi packet per day)
Occassionally alcoholic since 30yrs.


FAMILY HISTORY:

H/0 hemiparesis in grand father and father.


DRUG HISTORY:
No significant drug history.


GENERAL EXAMINATION:

Patient is conscious and co-operative.well oriented to time,place and person.
Moderately build and moderately nourished.


No pallor, icterus, cyanosis,clubbing, lymphadenopathy ,edema


VITALS

TEMPARATURE:Afebrile

BP:140/90 bpm 

PULSE RATE:80/min regular normal volume

RESPIRATORY RATE:16 cycles/min

Spo2 : 95%RA


CENTRAL NERVOUS SYSTEM:

Conscious and  coherent 

Right handed 

HIGHER MENTAL FUNCTIONS Intact.

MMSE 24/30


CRANIAL NERVE EXAMINATION:

1st : Normal

2nd : Visual acuity is normal

3rd,4th,6th : Pupillary reflexes present

               EOM full range of motion present        

5th : Sensory intact

          Motor intact

7th : There is absence of nasolabial fold in left side  and slight deviation of mouth towards right .

8th : No abnormality noted.

9th,10th,11th,12th : normal.


MOTOR EXAMINATION:

                           Right                        Left


                      UL          LL             UL      LL

 BULK:    Normal  Normal    Wasting in both 

TONE :   Normal  Normal  Hypertonic in both

 POWER :  5/5.         5/5.          3/5.          3/5


SUPERFICIAL REFLEXES:

CORNEAL present       

CONJUNCTIVAL present


DEEP TENDON REFLEXES:


                             Right                 Left


   BICEPS.               + 2                   + 3                 


   TRICEPS              + 2                   + 3                         


   KNEE                     + 3                   +3   


  ANKLE                   + 2                      +3


PLANTAR             Flexion                  Extension  

https://youtube.com/shorts/MWi6csdneKI?feature=share4


https://youtube.com/shorts/L9VKzyXRt_w?feature=share4


https://youtube.com/shorts/3R5VfOPGimY?feature=share4

    


SENSORY EXAMINATION:  



SPINOTHALAMIC SENSATION:

Crude touch Present 

Pain Present 

Temperature Present 

DORSAL COLUMN SENSATION:

Fine touch Present 

Vibration Present 

Proprioception Present 

CORTICAL SENSATION:


Two point discrimination Present 

Tactile localisation Present 

CEREBELLAR EXAMINATION:


 Finger nose test able to perform 

 Heel knee test able to perform

https://youtu.be/6IUtiGy19K0

Dysdiadochokinesia Absent 

Speech Normal 

Rhombergs test Absent


SIGNS OF MENINGEAL IRRITATION: 

Kernig's sign, brudzinski sign, neck rigidity

 absent 


RESPIRATORY SYSTEM:Bilateral air entry present,vesicular breath sounds heard, no adventitious sounds heard. 


CARDIOVASCULAR SYSTEM:

S1 ans S2 heart sounds heard,no murmurs heard 


ABDOMINAL EXAMINATION:

Soft and non tender,No organomegaly


PROVISIONAL DIAGNOSIS

Left Hemiparesis associated with UMN Facial palsy ( left side of face)

Acute ischemic stroke in right MCA territory??


INVESTIGATION


LIPID PROFILE

Total Cholesterol  152 mg/dL
Triglycerides # 172 mg/dL
HDL cholesterol # 39.7 mg/dL
LDL cholesterol 91.8 mg/dL
VLDL 34.4 mg/dL

COMPLETE BLOOD PICTURE

Haemoglobin 14.2 mg/dL
Total count 9000 cells/cu.mm
Neutrophils 60
Lymphocytes #19
Eosinophils #12
Basophils 0
Platelet count 2.79 lakhs / cu.mm
Smear Normocytic Normochromic 

RANDOM BLOOD SUGAR
125 mg/dl

SERUM CREATININE 1.1 mg/dL
BLOOD UREA 33 mg/dL

LIVER FUNCTION TESTS 

Total Bilirubin 0.98 mg/dL
Direct Bilirubin 0.18 mg/dL
SGOT 13 IU/L
SGPT 12 IU/L
Alkaline Phosphate #167 IU/L
Total proteins 6.7 gm/dL
Albumin 3.9 GM/dL
A/G 1.46

SERUM ELECTROLYTES

Na+ 135 mEq/L
K+ 4.4 mEq/L
Cl- 98 mEq/L
Ca+2 - 0.96 mmol/L


ECG


X RAY






Treatment

1. INJ OPTINEURON IV OD
(1 ampule in 100 mL NS)

2. TAB PREGABLIN 75mg po/HS

3. TAB ECOSPIRIN AV (75/20) po/Hs

4. TAB PAN 40mg po OD BBF

5. Physiotherapy of Left UL LL

BP PR RR charting 6th hrly


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